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A dose of the drug Ecstasy that is not normally deadly could call on fatal when taken in a hot , crowded setting , a fresh study in rats suggest .
investigator have thoughtecstasy , or MDMA , was fatal only in high doses , but the new cogitation found that even moderate disk operating system can be deadly in lovesome preferences that simulate the crowded social venues where people typically take the drug . Ecstasy may cause the body to overheat by restricting its ability to regulate temperature — a status shout hyperthermy , the researchers tell .
" Users tend to believe that [ MDMA ] is fairly safe when used in temperance and that serious inauspicious health complications , including pathologic hyperthermia , result from contamination of MDMA by other ' more dangerous ' drug , " said study researcher Eugene Kiyatkin , a scientist at the National Institute on Drug Abuse . " Contrary to popular opinion , MDMA could become very dangerous even at relatively abject or moderate doses , " when it is used in a warm , humid environment , Kiyatkin told Live Science .
Kiyatkin and colleague compared MDMA ’s effects on male rats in two different surroundings : The first was a standard research laboratory setting that was cool and quiet ; the second was a highly social setting , with hotter temperature and another scab present . Kiyatkin sound out the 2nd environment is a more realistic representation of the conditions in which humans typically use MDMA , like party and raves.[The Drug Talk : 7 New Tips for Today ’s parent ]
In a coolheaded surround , MDMA modestly increase the rat ' wit and body temperature , and rat variegate in how they react to the drug . But in a warm environment , the same dose render a more logical and observe effect : MDMA increased the rats ' head and body temperatures , causing some rats to pall .
The researchers hypothesize that , combined with the pressure of the raging environs , MDMA trammel the rats ' power to eliminate excessive heat from their bodies and properly shape their temperatures — a cooling mechanism that should be raw to the human and rat body . As a result , the rats ' consistence and Einstein temperatures wax sharply , causing their principal electronic organ to shut down .
Scientists antecedently linked MDMA - relate overheating or hyperthermia to high Elvis of the drug . Hyperthermia can precede to liver , kidney orcardiovascular systemfailures , as well as death .
Kiyatkin observe that the presence of another rat also amplified the heating effect in the rats . This could be because societal fundamental interaction tends to put individuals in a highly emotional state before and after taking the drug . " MDMA is often used in company with other people , which sum up to the stressfulness of drug intake , " Kiyatkin pronounce . MDMA can also affect the organic structure by increase sum rate or stemma atmospheric pressure and producing symptom of muscle tensity , nausea , chills and faintness .
In the brain , MDMA prompts a upsurge inserotonin , a neurotransmitter or chemical substance courier that journey across brainpower cell to aid regulate mood , emotion , anxiety , memory and perceptions . A serotonin surge grow the elevated feeling of ecstasy or felicity associated with using MDMA .
The cogitation was published June 4 in the Journal of Neuroscience .
